Genotypic and phenotypic characterization of Staphylococcus epidermidis causing chronic relapsing prosthetic joint infections

Autor:	Nathalie Asseray, Alain Reynaud, Stéphane Corvec, Pascale Bémer, Julie Marraillac, M.-E. Juvin, Benoît Henry, David Boutoille, Lise Crémet, Aurélie Guillouzouic, Sophie Touchais
Rok vydání:	2012
Předmět:	Male Microbiology (medical) Prosthesis-Related Infections medicine.drug_class Prosthetic joint Arthroplasty Replacement Hip Joint Prosthesis Antibiotics Clone (cell biology) Biology medicine.disease_cause Microbiology Antibiotic resistance Recurrence Risk Factors Staphylococcus epidermidis Genotype medicine Humans Arthroplasty Replacement Knee Aged Retrospective Studies Aged 80 and over General Immunology and Microbiology General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition biology.organism_classification Virology Phenotype Electrophoresis Gel Pulsed-Field Infectious Diseases Superinfection Chronic Disease Female
Zdroj:	Scandinavian Journal of Infectious Diseases. 44:610-614
ISSN:	1651-1980 0036-5548
DOI:	10.3109/00365548.2012.664778
Popis:	Twenty-one isolates of Staphylococcus epidermidis from 9 patients with persistent prosthetic joint infections were analysed by pulsed-field gel electrophoresis and antibiotic susceptibility assays. In 7 of these cases, the S. epidermidis isolate was different from that of the initial episode. In 1 further case, the superinfection was polyclonal. Recurrence, i.e., renewed isolation of a clone identical to that of an initial episode, occurred in 3 cases, 1 of which was in the absence of superinfection. A high degree of antibiotic resistance was demonstrated, including methicillin in 17 of 21 strains. In conclusion, a frequent occurrence of superinfection and a high degree of resistance make management of these infections complex.
Databáze:	OpenAIRE
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