Longer term effectiveness of inpatient multidisciplinary rehabilitation on health-related quality of life in MS patients: a pragmatic randomized controlled trial – The Danish MS Hospitals Rehabilitation Study

Autor: Philipp Trénel, Finn Boesen, Peter Vestergaard Rasmussen, Brita Løvendahl, Jan Sørensen, Thor Petersen, Michael Nørgaard
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Denmark
medicine.medical_treatment
Hospitals
Rehabilitation
multiple sclerosis
inpatient
rehabilitation
law.invention
Treatment and control groups
Danish
03 medical and health sciences
0302 clinical medicine
Quality of life
Randomized controlled trial
law
Outcome Assessment
Health Care
Outpatients
medicine
Humans
030212 general & internal medicine
pragmatic clinical trial
Rehabilitation Study
Patient Care Team
Inpatients
Rehabilitation
Expanded Disability Status Scale
Multidisciplinary rehabilitation
business.industry
Multiple sclerosis
Neurological Rehabilitation
Middle Aged
medicine.disease
language.human_language
quality of life
Neurology
randomized controlled trial
Quality of Life
Physical therapy
language
Female
Neurology (clinical)
business
Original Research Papers
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Multiple Sclerosis (Houndmills, Basingstoke, England)
Boesen, F, Nørgaard, M, Trénel, P, Rasmussen, P V, Petersen, T, Løvendahl, B & Sørensen, J 2018, ' Longer term effectiveness of inpatient multidisciplinary rehabilitation on health-related quality of life in MS patients : a pragmatic randomized controlled trial – The Danish MS Hospitals Rehabilitation Study ', Multiple sclerosis, vol. 24, no. 3, pp. 340-349 . https://doi.org/10.1177/1352458517735188
ISSN: 1477-0970
1352-4585
DOI: 10.1177/1352458517735188
Popis: Background: There is insufficient evidence to support the effectiveness of multidisciplinary rehabilitation on the health-related quality of life (HRQoL) of MS patients. Objectives: To evaluate the longer term effectiveness of inpatient multidisciplinary rehabilitation on the HRQoL of MS patients. Methods: The study was a two-hospital, pragmatic, randomized controlled trial with a 6-month follow-up. Patients aged 18–65 years with MS and Expanded Disability Status Scale scores ≤7.5 were randomly assigned (1:1) to 4 weeks of inpatient multidisciplinary rehabilitation (20 days of scheduled rehabilitation) or 6 months on a wait list. The outcome measures were Functional Assessment in Multiple Sclerosis (FAMS), Multiple Sclerosis Impact Scale-29 (MSIS-29), EQ-5D-5L and 15D. Results: We randomized 213 patients to the wait-list control group and 214 patients to the treatment group. Trends in favour of the treatment group were observed across all measures. However, the difference was significant in only two of the six measures. The treatment effect was −2.7 (95% CI: −5.6 to (−0.1)), p = 0.046) for the MSIS-29 Psychological and 0.017 (95% CI: 0.005–0.030, p = 0.008) for the 15D. FAMS, which we used to calculate the sample size, was not significant. Conclusion: The results indicated that inpatient multidisciplinary rehabilitation is effective in improving the HRQoL of MS patients after 6 months.
Databáze: OpenAIRE
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