Effects of complement regulators and chemokine receptors in type 2 diabetes
| Autor: | Ender Coskunpinar, S. Bilgic Gazioglu, Bedia Cakmakoglu, Günnur Deniz, Y Musteri Oltulu, B Aydin Ozgur, Mustafa Yilmaz, Akar Yilmaz, Ali Osman Gürol |
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| Přispěvatelé: | Tıp Fakültesi |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Receptors CXCR4 Stromal cell Genotype Immunology Activation chemical and pharmacologic phenomena CD59 Antigens Expression Progenitors Type 2 diabetes CD59 Biology Proteins Cd55 03 medical and health sciences Chemokine receptor 0302 clinical medicine Gene Frequency Diabetes mellitus medicine Humans Gene Variant Genetic Predisposition to Disease Polymorphism Aged Onset Polymorphism Genetic CD55 Antigens COMPLEMENT REGULATORS General Medicine Middle Aged medicine.disease Chemokine CXCL12 Complement (complexity) Oxidative Stress 030104 developmental biology Factor-I Diabetes Mellitus Type 2 Cardiovascular Diseases 030220 oncology & carcinogenesis Female Peripheral-Blood Cells |
| Popis: | CD55 and CD59 are complement regulatory proteins suggested to be related with progression of diabetes and its complications. The stromal cell-derived factor 1 (SDF-1) and C-X-C chemokine receptor type 4 (CXCR4) are chemokine proteins. We aimed to investigate the relation of CD55 and CD59 expression levels and polymorphisms of SDF-1 and CXCR-4 with type 2 diabetes mellitus (T2DM) and its complications. Seventy-five T2DM patients and 73 controls were enrolled. Expression levels of CD55 and CD59 were measured by FACS Calibur; qRT-PCR was used to determine SDF-1 and CXCR-4 gene polymorphisms. CD55 and CD59 expressions in patients with nephropathy, retinopathy and cardiovascular disease were significantly lower than controls. Frequency of CXCR-4 T allele carrying was high in patients and created 1.6 fold risk for the disease (p = .07). CXCR-4 a allele carriers had decreased nephropathy; although there was no statistical significance in carrying CXCR-4 T allele, presence of nephropathy was approximately 2 times higher (p = .254). The nephropathy risk increased 10-fold in CXCR-4 TT genotype carriers (p = .02). All SDF-1 CC genotype carriers had retinopathy, so, it was considered that the CC genotype was effective in retinopathy development (p = .031). For the presence of cardiovascular disease, significant difference was observed for SDF-1 genotypes. Increased cardiovascular risk of 5- and 1.9-fold in SDF-1 T (p = .007) and CXCR-4 T (p = .216) allele carriers, respectively, was observed. We suggest that CD55 and CD59 protein levels and SDF-1 and CXCR-4 have predictive importance in process, complications and tendency of T2DM. |
| Databáze: | OpenAIRE |
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