Impact of Cassia acutifolia Infusion on Glucose Levels in Obesity and Diabetes Rat Model
| Autor: | Ávila-González Ana Elisa, García-Cobián Teresa Arcelia, Barajas-Vega Jessica Lucía, Rodríguez-Razón Christian Martín, Ramírez-Lizardo Ernesto Javier, Rubio Arellano Edy David, Raffoul-Orozco Abdel Kerim |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
obesity DM2 Rat model lcsh:Medicine Negative control 030226 pharmacology & pharmacy Transaminase Cassia acutifolia 03 medical and health sciences 0302 clinical medicine Cassia Diabetes mellitus Internal medicine Medicine Adverse effect lcsh:Miscellaneous systems and treatments Pharmacology biology business.industry lcsh:R lcsh:RM1-950 lcsh:RZ409.7-999 medicine.disease biology.organism_classification Obesity Decreased creatinine lcsh:Therapeutics. Pharmacology Endocrinology Complementary and alternative medicine 030220 oncology & carcinogenesis Original Article business |
| Zdroj: | Journal of Pharmacopuncture Journal of Pharmacopuncture, Vol 20, Iss 3, Pp 201-206 (2017) |
| ISSN: | 2234-6856 2093-6966 |
| Popis: | Objectives The aim of this study was to investigate the effects of Cassia acutifolia on the obesity and the glucose levels in a rat model of obesity and diabetes. Methods By random selection, 36 Wistar male rats were divided in two control groups, the positive and the negative control groups, and into four experimental groups receiving different infusions of Cassia acutifolia in water ad libitum. Results The results revealed a statistically significant anti-obesogenic effect (P = 0.02), although this was not considered clinically significant. Additionally, Cassia acutifolia lowered the glucose levels by 30 mg/dL to 90 mg/dL (P = 0.05). However, we observed adverse effects in the liver, a two-fold increase in transaminase levels (P = 0.002), and in the kidneys, decreased creatinine levels (P = 0.001), and these adverse effects had no viable explanation. Conclusion Cassia acutifolia has anti-hyperglycemic effects in obese diabetic rats. However, Cassia acutifolia also has adverse effects, so it should not be administered to patients. |
| Databáze: | OpenAIRE |
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