AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces
| Autor: | Satoshi Omura, Akira Nakagawa, Hideki Shimizu, Kiyoizumi Hinotozawa, Hiroshi Hashimoto, Kazuhiko Otoguro, Yuzuru Iwai |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Chemical Phenomena
medicine.drug_class Antibiotics Antiviral Agents Streptomyces Microbiology Lactones Mice chemistry.chemical_compound Column chromatography Drug Discovery medicine Animals Pharmacology Bacteria biology Strain (chemistry) Chemistry Physical Silica gel RNA biology.organism_classification In vitro Anti-Bacterial Agents Biochemistry chemistry Fermentation Viruses Macrolides DNA |
| Zdroj: | The Journal of Antibiotics. 35:1632-1637 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.35.1632 |
| Popis: | A novel antibiotic, AM-2604 A was isolated from the fermentation broth of Streptomyces sp. AM-2604 by solvent extraction and silica gel column chromatography. The antibiotic is pale yellow needles possessing UV absorption maxima at 280 nm and 330 nm (sh). The antibiotic possesses weak activity against fungi and trichomonad and potent inhibitory activity against various RNA and DNA viruses in vitro. |
| Databáze: | OpenAIRE |
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