Impaired cutaneous wound healing in mice lacking tetranectin
| Autor: | Toshihiko Yamashita, Ulla M. Wewer, Takuro Wada, Norimasa Sawada, Tadaki Matsumura, Naoko Hatakeyama, Masaki Murata, Kousuke Iba, Takashi Kojima |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Null mice Dorsum Wound Healing medicine.medical_specialty Pathology integumentary system Epidermis (botany) Reverse Transcriptase Polymerase Chain Reaction business.industry Dermatology Surgery Mice Tissue remodeling Models Animal Animals Medicine Lectins C-Type Targeted disruption Cutaneous wound business Wound healing Plasminogen activator Skin |
| Zdroj: | Wound Repair and Regeneration. 17:108-112 |
| ISSN: | 1524-475X 1067-1927 |
| DOI: | 10.1111/j.1524-475x.2008.00447.x |
| Popis: | Tetranectin was originally purified from human serum on the basis of plasminogen kringle 4-binding properties. Tetranectin enhances plasminogen activation by a tissue-type plasminogen activator so that it has been suggested to play a role in tissue remodeling. We have generated mice with a targeted disruption of the tetranectin gene to elucidate the biological function of tetranectin. In this study, we showed that wound healing was markedly delayed in tetranectin-null mice compared with wild-type mice. A single full-thickness incision was made in the dorsal skin. By 14 days after the incision, the wounds fully healed in all wild-type mice based on the macroscopic closure; in contrast, the progress of wound healing in the tetranectin null mice appeared to be impaired. In histological analysis, wounds of wild-type mice showed complete reepithelialization and healed by 14 days after the incision. However, those of tetranectin-null mice never showed complete reepithelialization at 14 days. At 21 days after the injury, the wound healed and was covered with an epidermis. These results supported the fact that tetranectin may play a role in the wound healing process. |
| Databáze: | OpenAIRE |
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