Failure of pretreatment with propranolol to reduce the zone of myocardial infarction after 2 hours of coronary occlusion in the primate heart
| Autor: | Grayson G. Geary, Lynne Fenton, Benjamin Siu, Gary Cheng, J. Judson McNamara, Gregory T. Smith |
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| Rok vydání: | 1983 |
| Předmět: |
Coronary artery occlusion
medicine.medical_specialty Time Factors Premedication Myocardial Infarction Collateral Circulation Blood Pressure Propranolol Loading dose Heart Rate Internal medicine Heart rate medicine Animals Myocardial infarction business.industry Myocardium medicine.disease Constriction Coronary Vessels Myocardial Contraction Regimen Coronary occlusion Anesthesia Cardiology Cardiology and Cardiovascular Medicine business Papio medicine.drug |
| Zdroj: | The American Journal of Cardiology. 52:615-620 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(83)90037-1 |
| Popis: | The present study assessed the value of pretreatment with propranolol to reduce ultimate myocardial infarct size after acute coronary artery occlusion in the primate heart. An experimental group of 8 baboons was administered a 2-mg/kg loading dose of propranolol intravenously over a 20-minute period before coronary occlusion. This regimen resulted in (1) a decrease in heart rate from 104 ± 19 to 73 ± 8 beats/min (mean ± standard deviation) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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