Proinflammatory cytokines (IL-1β and TNF-α) and chemokines (IL-8 and MIP-1α) as markers of peri-implant tissue condition
| Autor: | Danilo Vojvodic, Novak Stamatovic, Zoran Lazic, R.J. Kozomara, A.B. Petković, Tatjana Todorovic, Smiljana Matic |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Mucositis Pathology medicine.medical_specialty Peri-implantitis medicine.medical_treatment Interleukin-1beta Bleeding on probing Inflammation Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Humans Medicine Dental Restoration Failure Periodontitis Chemokine CCL3 030304 developmental biology Dental Implants Stomatitis 0303 health sciences Tumor Necrosis Factor-alpha business.industry Dental Implantation Endosseous Interleukin-8 Implant failure Gingival Crevicular Fluid 030206 dentistry Middle Aged medicine.disease 3. Good health Cytokine Otorhinolaryngology Cytokines Female Surgery Implant Inflammation Mediators Periodontal Index Oral Surgery medicine.symptom business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 39:478-485 |
| ISSN: | 0901-5027 |
| Popis: | Analysis of peri-implant crevicular fluid (PICF) offers a non-invasive means of studying the host response in peri-implant disease and may provide an early indication of patients at risk for active disease. This study examined the PICF levels of interleukin-1beta (IL-1beta), tumour necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8) and macrophage inflammatory protein-1alpha (MIP-1alpha) in patients with non-manifesting inflammation, early and late stages of mucositis. The study group comprised 90 adult healthy volunteers with endosseal titanium implants inserted. Samples were taken from peri-implant sulcus using a filter paper technique. Implant tissues were categorized clinically as healthy, early mucositis or advanced mucositis. Clinical manifestations were determined by: gingival index and bleeding on probing, plaque index and radiographic analyses. Cytokine concentrations were assesed using commercially available enzyme-linked immunosorbent assay kits. Patients from the control group (healthy patients) have significantly lower concentrations of IL-1beta, TNF-alpha, IL-8 and MIP-1alpha in PICF compared with both groups with mucositis. Positive correlation was noted in the control group between IL-1beta and TNF-alpha and between MIP-1alpha and IL-8 in the group with early mucositis. The results suggest that cytokines could be prognostic markers of implant failure. |
| Databáze: | OpenAIRE |
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