Effect of renal function on high-density lipoprotein particles in patients with coronary heart disease
| Autor: | Li Li, Liu Dan, Zeng Xiaorong, Xue Yazhi, Guo Zhi-gang, Rao Jiahuan, Long Jieni, Zhang Bin, Ma Yusheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Renal function Coronary Artery Disease Kidney Logistic regression chemistry.chemical_compound High-density lipoprotein Internal medicine Humans Medicine Diseases of the circulatory (Cardiovascular) system Renal insufficiency Angiology Apolipoprotein A-I business.industry Research nutritional and metabolic diseases Middle Aged medicine.disease Cardiac surgery Coronary heart disease chemistry RC666-701 Cardiology HDL particles Female lipids (amino acids peptides and proteins) HDL-C/apoA-I Lipoproteins HDL Cardiology and Cardiovascular Medicine business Dyslipidemia Glomerular Filtration Rate Lipoprotein |
| Zdroj: | BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021) BMC Cardiovascular Disorders |
| ISSN: | 1471-2261 |
| Popis: | Background Although renal insufficiency and dyslipidemia are known to be closely associated, the effect of kidney function on the size and clinical value of high-density lipoprotein (HDL) particles remains largely unknown, especially in patients with coronary heart disease. Methods A total of 419 coronary heart disease patients and 105 non-coronary heart disease patients were included. HDL particle size, represented by HDL-C/apoA-I, was compared between groups stratified by estimated glomerular filtration rate (eGFR) and Gensini scores using standard Student’s t test and one-way ANOVA. Pearson’s correlation test was performed to analyze the association between eGFR and HDL-C/apoA-I in patients with coronary heart disease. The relationship between HDL particle size and the occurrence of coronary heart disease was explored using Univariate logistic regression analysis. Results In patients with coronary heart disease, between-group analysis revealed that HDL-C/apoA-I increased as eGFR declined, and significance appeared as eGFR declined to under 60 ml/min·1.73 m2 (P 2), those with higher Gensini scores had smaller HDL-C/apoA-I. However, with or without kidney insufficiency, smaller HDL-C/apoA-I was associated with a higher occurrence of coronary heart disease (P Conclusion With the presence of renal insufficiency, HDL-C/apoA1 was higher in patients with coronary heart disease. Lower HDL-C/apoA1 was still associated with a higher occurrence of coronary heart disease, but the original association between lower HDL-C/apoA1 and more severe coronary artery stenosis was lost in patients with renal insufficiency. |
| Databáze: | OpenAIRE |
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