Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study
| Autor: | Tetsuo Abe, Tetsuya Suhara, Yasuhiko Sudo, Yasuhiro Someya, Yoshiro Okubo, Kunihiko Asai, Tomoyuki Saijo, Takeshi Sassa, Takehiko Shuno |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Cerebral Ventricles Lateral ventricles Internal medicine Brief Psychiatric Rating Scale medicine Humans Anthropometry medicine.diagnostic_test General Neuroscience Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Surgery Psychiatry and Mental health Neurology Schizophrenia Ventricular enlargement Chronic Disease Laterality Disease Progression Cardiology Female Neurology (clinical) Psychology Follow-Up Studies |
| Zdroj: | Psychiatry and Clinical Neurosciences. 55:41-47 |
| ISSN: | 1440-1819 1323-1316 |
| Popis: | Recent studies of the brain using magnetic resonance imaging (MRI) have suggested progressive structural changes in schizophrenics. However, those studies were conducted over periods of less than 5 years and thus lacked sufficient capacity to determine the course and nature of this process. In this study, MRI scans were obtained in 15 schizophrenics and 12 controls at baseline and after 4- and 10-year follow ups. Volumes of the lateral ventricles were measured. Patients were assessed by the Brief Psychiatric Rating Scale (BPRS) at the same two time points: at baseline and at 10-year follow up. After 10 years, a significant lateral ventricular enlargement was found in patients (mean percentage change: +22.9%) but not in controls (5.1%). Although our results are not in disagreement with the neurodevelopmental hypothesis, they do provide strong evidence that in schizophrenia progressive brain reduction occurs even in its chronic stage. |
| Databáze: | OpenAIRE |
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