Brain iron content in systemic iron overload: A beta-thalassemia quantitative MRI study
| Autor: | Maddalena Casale, Immacolata Tartaglione, Sara Ponticorvo, Rosanna Di Concilio, Silverio Perrotta, Renzo Manara, Andrea Elefante, Mario Cirillo, Pasquale Alessandro Carafa, Gianluca Femina, Nikolaus Weiskopf, Francesco Di Salle, Angela Ciancio, Elisa De Michele, Camilla Russo, Fabrizio Esposito |
|---|---|
| Přispěvatelé: | Manara, R., Ponticorvo, S., Tartaglione, I., Femina, G., Elefante, A., Russo, C., Carafa, P. A., Cirillo, M., Casale, M., Ciancio, A., Di Concilio, R., De Michele, E., Weiskopf, N., Di Salle, F., Perrotta, S., Esposito, F. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Red nucleus Thalassemia Caudate nucleus Physiology Hippocampus Iron poisoning lcsh:RC346-429 chemistry.chemical_compound 0302 clinical medicine hemic and lymphatic diseases Putamen 05 social sciences Blood transfusion Beta thalassemia Wechsler Adult Intelligence Scale Brain Regular Article Middle Aged Magnetic Resonance Imaging Neurology lcsh:R858-859.7 Female Deferiprone Human Adult congenital hereditary and neonatal diseases and abnormalities Iron Overload Adolescent Cognitive Neuroscience Iron lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 03 medical and health sciences Young Adult Hippocampu medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Brain Chemistry business.industry beta-Thalassemia Multi-parametric mapping medicine.disease chemistry Brain MRI Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 24, Iss, Pp-(2019) NeuroImage: Clinical NeuroImage : Clinical |
| Popis: | Highlights • Iron overload is a life-threatening condition in beta-thalassemia. • Data on brain involvement in systemic iron overload are conflicting. • MRI quantification of brain tissue iron content is feasible in a voxel-based approach. • No iron tissue excess is evident in beta-thalassemia but in the choroid plexuses. Objective Multisystem iron poisoning is a major concern for long-term beta-thalassemia management. Quantitative MRI-based techniques routinely show iron overload in heart, liver, endocrine glands and kidneys. However, data on the brain are conflicting and monitoring of brain iron content is still matter of debate. Methods This 3T-MRI study applied a well validated high-resolution whole-brain quantitative MRI assessment of iron content on 47 transfusion-dependent (mean-age: 36.9 ± 10.3 years, 63% females), 23 non-transfusion dependent (mean-age: 29.2 ± 11.7 years, 56% females) and 57 healthy controls (mean-age: 33.9 ± 10.8 years, 65% females). Clinical data, Wechsler Adult Intelligence Scale scores and treatment regimens were recorded. Beside whole-brain R2* analyses, regional R2*-values were extracted in putamen, globus pallidum, caudate nucleus, thalamus and red nucleus; hippocampal volumes were also determined. Results Regional analyses yielded no significant differences between patients and controls, except in those treated with deferiprone that showed lower R2*-values (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|