The apoptosis of grass carp (Ctenopharyngodon idella) muscle during postmortem condition regulated by the cytokines via TOR and NF-κB signaling pathways
| Autor: | Yanshun Xu, Fang Yang, Qixing Jiang, Wenshui Xia, Huai-Mao Tie, Dawei Yu, Rong-Xin Sun |
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| Rok vydání: | 2021 |
| Předmět: |
Fish Proteins
Carps Inflammation Apoptosis Analytical Chemistry Fish Diseases medicine Transcriptional regulation Animals Caspase biology Muscles NF-kappa B General Medicine biology.organism_classification Animal Feed Immunity Innate Grass carp Cell biology Aeromonas hydrophila Diet Nf κb signaling medicine.anatomical_structure Dietary Supplements biology.protein DNA fragmentation Cytokines medicine.symptom Gram-Negative Bacterial Infections Nucleus Food Science |
| Zdroj: | Food chemistry. 369 |
| ISSN: | 1873-7072 |
| Popis: | Postmortem alteration by apoptosis has significant effects on flesh quality. Currently, the information necessary to understand the apoptotic behavior and the molecular mechanisms during postmortem alteration in fish muscle is still lacking. Activation of apoptosis and the cytokines involved in regulating apoptosis in fish muscle were evaluated during postmortem condition at 4 °C for 5 days in terms of apoptotic morphology changes, nucleus DNA fragmentation, caspases activation and related gene expressions. The triggering apoptotic mechanisms associated with multiple cytokines transcriptional levels showed that the up-regulated pro-apoptotic mediators [IFN-γ2, TNF-α, IL-6, IL-1β, IL-17D, IL-12p35 and IL-10 (except IL-15)] and the down-regulated anti-apoptotic mediators of [IL-8 and IL-11 (except TGF-β and IL-4)] both regulated apoptosis at early stage, which were regulated by NF-κB and TOR, respectively. Results suggested that transcriptional regulation of multiple cytokines produce a positive outcome on triggering apoptosis. |
| Databáze: | OpenAIRE |
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