Primary Thyroid Lymphoma Is a Heterogeneous Disease
| Autor: | A Mayer, Catherine Thieblemont, Françoise Berger, Bertrand Coiffier, C Martin, Gilles Salles, Pascale Felman, Evelyne Callet-Bauchu, Charles Dumontet, Y. Barbier, J Orgiazzi, X Ducottet |
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| Rok vydání: | 2002 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pathology Goiter Lymphoma endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Follicular lymphoma Biochemistry Endocrinology Hypothyroidism Thyroid lymphoma immune system diseases hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Hashimoto Disease Disseminated disease Thyroid Neoplasms Cyclophosphamide Lymphoma Follicular Retrospective Studies business.industry Biochemistry (medical) MALT lymphoma Lymphoma B-Cell Marginal Zone Middle Aged Prognosis medicine.disease Survival Analysis Doxorubicin Vincristine Thyroidectomy Prednisone Female Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma Goiter Nodular |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 87:105-111 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.87.1.8156 |
| Popis: | We retrospectively analyzed 26 patients with thyroid lymphoma (TL). Patients were mostly females, with a median age of 59 yr, presenting a rapidly growing nodular goiter with or without cervical adenopathy, without symptoms related to lymphoma for 81% and hypothyroidism in 61%. A previous history of Hashimoto thyroiditis was observed in 11 patients. Six different subtypes of lymphoma were observed: 13 of 26 (50%) had diffuse large B cell lymphoma, 6 (23%) mucosa- associated lymphoid tissue (MALT) lymphoma, 3 (12%) had follicular lymphoma, 2 (7%) had Hodgkin's disease, 1 (4%) had small lymphocytic lymphoma, and 1 (4%) had Burkitt's lymphoma. Diffuse large B cell lymphoma patients presented a compressive multinodular goiter, cervical adenopathy (66%), disseminated disease (50%), and poor performance status, with a poor prognosis (5-yr survival at 44%) despite a treatment based on a multidrug regimen. MALT lymphoma arose in patients with previous history of Hashimoto disease, was localized in all but 1, and was biologically associated with hypothyroidism and a high level of serum antithyroid antibodies. With total thyroidectomy, prognosis was good (5-yr survival at 100%). We did not find any routine clinical or biological parameters that could predict the evolution from Hashimoto's thyroiditis to MALT lymphoma. In conclusion, we confirmed the histological heterogeneity of TL corresponding to different clinical presentations and different prognoses. |
| Databáze: | OpenAIRE |
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