Hard-diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft-diet feeding
| Autor: | Tomohiro Noguchi, Sadaharu Miyazono, Makoto Kashiwayanagi, Chizuru Utsugi, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Olfactory system
Time Factors lcsh:Medicine Stimulation 旭川医科大学：博士（医学）甲第467号 Trigeminal Nuclei Mice Lateral Ventricles Neurobiology of Disease and Regeneration Medicine and Health Sciences lcsh:Science Multidisciplinary Neurogenesis Animal Models Immunohistochemistry Olfactory Bulb Stimulation Chemical Sensory Systems Smell medicine.anatomical_structure Neurology Female Research Article medicine.medical_specialty Oral Medicine Subventricular zone Mouse Models Sensory system Biology Research and Analysis Methods 学位授与年月日：平成26年6月30日 Model Organisms Developmental Neuroscience Internal medicine medicine Animals Mastication Analysis of Variance Olfactory System lcsh:R Soft diet Biology and Life Sciences Diet Olfactory bulb Mice Inbred C57BL Endocrinology Bromodeoxyuridine nervous system Cellular Neuroscience Dentistry Butyric Acid lcsh:Q Neuroscience |
| Zdroj: | PLoS ONE, Vol 9, Iss 5, p e97309 (2014) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal sensory trigeminal nucleus (Pr5), which receives intraoral touch information via the trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB. |
| Databáze: | OpenAIRE |
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