Soft-tissue-mimicking using silicones for the manufacturing of soft phantoms by fresh 3D printing

Autor: Christophe A. Marquette, Edwin-Joffrey Courtial, Arthur Colly, Aitor Tejo-Otero, Irene Buj-Corral, Felip Fenollosa-Artés
Přispěvatelé: Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Ingénierie des Matériaux Polymères (IMP), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya. Departament d'Enginyeria Mecànica, Universitat Politècnica de Catalunya. Doctorat en Enginyeria Mecànica, Fluids i Aeronàutica, Universitat Politècnica de Catalunya. TECNOFAB - Grup de Recerca en Tecnologies de Fabricació
Rok vydání: 2021
Předmět:
Materials science
Tissue mimicking phantom
0206 medical engineering
Silicones
3D printing
New materials
02 engineering and technology
FRESH
Industrial and Manufacturing Engineering
Imaging phantom
Embedded
chemistry.chemical_compound
Silicone
Liver tissue
Pluronic® F-127
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Dynamic mechanical analysis
PluronicV R F-127
business.industry
Materials--Propietats mecàniques
Mechanical Engineering
Soft tissue
equipment and supplies
Shear rheometry
021001 nanoscience & nanotechnology
020601 biomedical engineering
Organ phantoms
3D Printing
Manufacturing
[CHIM.POLY]Chemical Sciences/Polymers
chemistry
Self-healing hydrogels
Enginyeria mecànica::Processos de fabricació mecànica [Àrees temàtiques de la UPC]
0210 nano-technology
business
Materials--Mechanical properties
Biomedical engineering
Zdroj: Rapid Prototyping Journal
Rapid Prototyping Journal, Emerald, In press, ⟨10.1108/RPJ-04-2021-0079⟩
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
ISSN: 1355-2546
DOI: 10.1108/rpj-04-2021-0079
Popis: Purpose The purpose of this study is to use the Freeform Reversible Embedding of Suspended Hydrogels (FRESH) additive manufacturing (AM) technique for manufacturing a liver phantom which can mimic the corresponding soft living tissue. One of the possible applications is surgical planning. Design/methodology/approach A thermo-reversible Pluronic® F-127-based support bath is used for the FRESH technique. To verify how three-dimensional (3D)-printed new materials can mimic liver tissue, dynamic mechanical analysis and oscillation shear rheometry tests are carried out to identify mechanical characteristics of different 3D printed silicone samples. Additionally, the differential scanning calorimetry was done on the silicone samples. Then, a validation of a 3D printed silicone liver phantom is performed with a 3D scanner. Finally, the surface topography of the 3D printed liver phantom was fulfiled and microscopy analysis of its surface. Findings Silicone samples were able to mimic the liver, therefore obtaining the first soft phantom of the liver using the FRESH technique. Practical implications Because of the use of soft silicones, surgeons could practice over these improved phantoms which have an unprecedented degree of living tissue mimicking, enhancing their rehearsal experience before surgery. Social implications An improvement in surgeons surgery skills would lead to a bettering in the patient outcome. Originality/value The first research study was carried out to mimic soft tissue and apply it to the 3D printing of organ phantoms using AM FRESH technique.
Databáze: OpenAIRE
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