Action of estrogen on survival of basal forebrain cholinergic neurons: promoting amelioration

Autor: Zsombor Kőszegi, István M. Ábrahám, Éva M. Szegő, Emeline Tolod-Kemp
Rok vydání: 2009
Předmět:
medicine.medical_specialty
medicine.drug_class
Endocrinology
Diabetes and Metabolism
Models
Biological
03 medical and health sciences
Amyloid beta-Protein Precursor
0302 clinical medicine
Endocrinology
Cognition
Prosencephalon
Alzheimer Disease
Internal medicine
Neuroplasticity
medicine
Amyloid precursor protein
Animals
Humans
Nerve Growth Factors
Cholinergic neuron
Biological Psychiatry
030304 developmental biology
0303 health sciences
Basal forebrain
Amyloid beta-Peptides
Neuronal Plasticity
biology
Endocrine and Autonomic Systems
Estrogens
Psychiatry and Mental health
Neuroprotective Agents
nervous system
Cholinergic Fibers
Estrogen
Second messenger system
biology.protein
Cholinergic
Psychology
Neuroscience
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Neurotrophin
Signal Transduction
Zdroj: Psychoneuroendocrinology. 34
ISSN: 1873-3360
Popis: Extensive studies during the past two decades provide compelling evidence that the gonadal steroid, estrogen, has the potential to affect the viability of basal forebrain cholinergic neurons. These observations reflect a unique ameliorative feature of estrogen as it restores and protects the cholinergic neurons against noxious stimuli or neurodegenerative processes. Hence, we first address the ameliorative function of estrogen on basal forebrain cholinergic neurons such as the actions of estrogen on neuronal plasticity of cholinergic neurons, estrogen-induced memory enhancement and the ameliorative role of estrogen on cholinergic neuron related neurodegenerative processes such as Alzheimer's disease. Second, we survey recent data as to possible mechanisms underlying the ameliorative actions of estrogen; influencing the amyloid precursor protein processing, enhancement in neurotrophin receptor signaling and estrogen-induced non-classical actions on second messenger systems. In addition, clinical relevance, pitfalls and future aspects of estrogen therapy on basal forebrain cholinergic neurons will be discussed.
Databáze: OpenAIRE
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