| Autor: |
Zhanna Shcheprova, Anne Daulny, Priyanka Sharma, Arun H.S. Kumar, Miguel Beato, Manuel Mendoza, Irene Matucci, Charlotta Funaya, Trinidad Sanmartin |
| Rok vydání: |
2017 |
| Předmět: |
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| Popis: |
SummaryThe acquisition of cellular identity is coupled to changes in the nuclear periphery and nuclear pore complexes (NPCs). Whether and how these changes determine cell fate remains unclear. We have uncovered a mechanism regulating NPC acetylation to direct cell fate after asymmetric division in budding yeast. The lysine deacetylase Hos3 associates specifically with daughter cell NPCs during mitosis to delay cell cycle entry (Start). Hos3-dependent deacetylation of nuclear basket and central channel nucleoporins establishes daughter cell-specific nuclear accumulation of the transcriptional repressor Whi5 during anaphase and perinuclear silencing of the CLN2 gene in the following G1 phase. Hos3-dependent coordination of both events restrains Start in daughter but not in mother cells. We propose that deacetylation modulates transport-dependent and - independent functions of NPCs, leading to differential cell cycle progression in mother and daughter cells. Similar mechanisms might regulate NPC functions in specific cell types and/or cell cycle stages in multicellular organisms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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