Neurochemical analysis of brain monoamines after L-histidine and chlorpheniramine administration in goldfish
| Autor: | Erika M. Santangelo, Rosana Mattioli, C.C. Medalha |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Telencephalon
medicine.medical_specialty Chlorpheniramine Serotonin medicine.medical_treatment Dopamine Down-Regulation Diencephalon chemistry.chemical_compound Neurochemical Internal medicine Goldfish medicine Animals Biogenic Monoamines Histidine Saline Neurons Chemistry General Neuroscience Dopaminergic Homovanillic acid Brain Homovanillic Acid Hydroxyindoleacetic Acid Monoamine neurotransmitter Endocrinology Anti-Anxiety Agents Catecholamine Histamine H1 Antagonists medicine.drug |
| Zdroj: | Neuroscience letters. 349(3) |
| ISSN: | 0304-3940 |
| Popis: | This study investigated the effects of chlorpheniramine (CPA) and L-histidine (LH) administration on catecholaminergic levels in goldfish brain using neurochemical analysis. Fifty-eight animals were used. After 20 min of i.p. administration of the drugs or saline the animals were decapitated, and the telencephalon and the diencephalon were dissected. We also measured catecholamines in a non-injected (NI) group. Results showed lower homovanillic acid (HVA) levels after treatment with 100 mg/kg of LH when compared to saline and 5-hydroxyindoleacetic acid levels were lower in the saline group when compared to the NI group. In the diencephalon the NI group and animals treated with CPA at 4.0 and 8.0 mg/kg had lower HVA levels. Results suggest that LH had an inhibitory effect on dopaminergic activity and an anxiolytic-like effect for CPA results is suggested. |
| Databáze: | OpenAIRE |
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