Characterization of altered calcium signalling in T lymphocytes from patients with rheumatoid arthritis (RA)
| Autor: | Paul A. Bacon, George D. Kitas, Stephen P. Young, W. G. Naylor, M. E. Allen, David Carruthers |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
CD3 Complex T-Lymphocytes CD3 T cell Immunology Population Peripheral blood mononuclear cell Arthritis Rheumatoid Immune system Internal medicine Calcium flux medicine Humans Immunology and Allergy Phytohemagglutinins education Phytohaemagglutinin education.field_of_study biology business.industry Original Articles T lymphocyte medicine.anatomical_structure Endocrinology biology.protein Calcium business |
| Zdroj: | Clinical and Experimental Immunology. 105:291-296 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.1996.d01-768.x |
| Popis: | Abnormal function of peripheral blood T lymphocytes is characteristic of RA; diminished proliferation and secretion of cytokines following in vitro mitogen stimulation are observed. We have investigated the calcium flux initiating T cell activation in rheumatoid peripheral blood mononuclear cells (PBMC) to determine whether abnormalities in signalling are also present. We have found that both phytohaemagglutinin (PHA-P)- and anti-CD3-stimulated calcium fluxes were much reduced in the patients’ PBMC compared with controls, with a mean six-fold difference (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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