Effects of Asherman Syndrome on Maternal and Neonatal Morbidity with Evaluation by Conception Method
| Autor: | Peter Movilla, S.N. Morris, Jennifer Wang, Keith B. Isaacson, T.Y. Chen, A. Williams, B. Morales, Joyce Wang, J. Tavcar, Himabindu Reddy, M. Loring |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Intrauterine growth restriction Fertilization in Vitro Gynatresia 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans education Retrospective Studies education.field_of_study 030219 obstetrics & reproductive medicine medicine.diagnostic_test Obstetrics business.industry Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Retrospective cohort study medicine.disease Gestational diabetes Hysteroscopy 030220 oncology & carcinogenesis Asherman Syndrome Premature Birth Apgar score Female Morbidity business |
| Zdroj: | Journal of minimally invasive gynecology. 28(7) |
| ISSN: | 1553-4669 |
| Popis: | Study Objective Create a comprehensive summary of maternal and neonatal morbidities from patients previously treated for Asherman syndrome and evaluate for differences in perinatal outcomes based on conception method. Design Retrospective cohort. Setting Community teaching hospital affiliated with a large academic medical center. Patients Total of 43 singleton births identified from 40 patients previously treated at our institution for Asherman syndrome. Interventions Review of fertility and obstetric data to summarize the maternal and neonatal outcomes in singleton births from patients with Asherman syndrome who had been treated with hysteroscopic adhesiolysis. Measurements and Main Results Primary outcomes of maternal morbidity (i.e., hypertensive disease, gestational diabetes, ruptured membranes, postpartum hemorrhage, morbidly adherent placenta [MAP]) and secondary outcomes of neonatal morbidity (i.e., gestational age at birth, method of delivery, weight, length, 1- and 5-minute Apgar score oxygen requirement, anatomic malformations, length of neonatal admission) were evaluated. We identified 40 patients who completed successful treatment of Asherman syndrome and went on to carry a singleton gestation within our institution: 20 (50%) with mild disease, 18 (45%) with moderate disease, and 2 (5%) with severe disease under the March classification system. In total, 43 singleton births were examined, with 27 of 43 (62.8%) conceived without in vitro fertilization (IVF) (group A: non-IVF conception) and 16 of 43 (37.2%) conceived through IVF (group B: IVF conception). The overall rate of preterm birth in Asherman pregnancies was 11.6%, with no difference between the 2 conception groups. We documented 9.3% cases with intrauterine growth restriction, with no difference based on conception groups. The rate of MAP in patients with Asherman syndrome was 14.0%, and the rate of postpartum hemorrhage was 32.6%, with no differences between the conception groups. Newborn anatomic malformations of any cause were documented in 18.6% of all singleton births, with no difference between the conception groups. Conclusion Our series indicates a higher incidence of intrauterine growth restriction, MAP, postpartum hemorrhage, and newborn anatomic malformations in Asherman syndrome pregnancies than that reported in pregnancies within the general population. However, we found no significant differences in the maternal and neonatal outcomes of patients with Asherman syndrome who conceived with or without IVF after being treated with hysteroscopic adhesiolysis. |
| Databáze: | OpenAIRE |
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