Associated leukemia and mixed gem cell tumor in a patient with gonadal dysgenesis
| Autor: | Sandra S. Kaplan, S.G. Bornstein, U. Surti, W.A. Christopherson |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Adolescent Acute myeloblastic leukemia Gonadal dysgenesis Biology Y chromosome XY gonadal dysgenesis Neoplasms Multiple Primary Internal medicine medicine Humans Yolk sac Gonadal Dysgenesis 46 XY Ovarian Neoplasms Obstetrics and Gynecology Karyotype General Medicine Neoplasms Germ Cell and Embryonal medicine.disease Leukemia Myeloid Acute Leukemia Endocrinology medicine.anatomical_structure Cancer research Female Germ cell tumors |
| Zdroj: | International Journal of Gynecology & Obstetrics. 35:83-88 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/0020-7292(91)90069-h |
| Popis: | A 16-year-old phenotypic female developed acute myeloblastic leukemia with a fulminant course very shortly after surgery and chemotherapy for a mixed germ cell tumor of the ovary. The karyotype (46, XY, 47, XY + 8) suggested de novo rather than therapy-associated leukemia. The relationship between germ cell tumors and leukemia, their common yolk sac derivation and the role of the Y chromosome are discussed. The idea that XY gonadal dysgenesis may be familial also is discussed. |
| Databáze: | OpenAIRE |
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