Methadone serum concentrations and influencing factors: A naturalistic observational study
| Autor: | Fatemeh Chalabianloo, Eirik Skogvoll, Andreas Austgulen Westin, Jørgen G. Bramness, Olav Spigset |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Methadone maintenance law.invention Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Pharmacokinetics law Internal medicine Opiate Substitution Treatment Humans Medicine Drug Interactions Adverse effect Aged Pharmacology Clinical pharmacology Norway business.industry Therapeutic effect Middle Aged Opioid-Related Disorders Confidence interval 030227 psychiatry Analgesics Opioid Concomitant Female business Methadone 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychopharmacology. 236:3159-3167 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-019-05277-1 |
| Popis: | Although methadone maintenance treatment (MMT) has long been used for opioid addiction, our knowledge on its pharmacokinetics is still limited. We aimed to investigate effects of age, gender, and various co-medications on methadone serum concentration-to-dose ratio (CDR) in a naturalistic setting. In total, 4425 routine serum methadone concentrations obtained from 1691 MMT patients in the period October 1999 to July 2017 were included. Information about doses, age, gender, and concurrent medications was available in the laboratory database at the Department of Clinical Pharmacology at St. Olav University Hospital in Trondheim, Norway. A log-linear mixed model was used when analyzing the data. Mean age was 38.4 (range, 21–78) years and 70% were men. Mean CDR was 332 (range, 7–1776) (ng/mL)/(100 mg/d). Concomitant medication with at least one out of totally 170 drugs was recorded in 26% of the samples. CDRs were significantly lower in women (− 9%; confidence interval (CI), − 13%, − 4%; p = 0.001) and with concurrent use of CYP inducers (− 36%; CI, − 44%, − 28%; p |
| Databáze: | OpenAIRE |
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