The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis

Autor: Ingo Bothe, Susanne Dietrich
Rok vydání: 2006
Předmět:
Head/*embryology
Myocardium/metabolism
Facial Muscles
Chick Embryo
Muscle Development
FGF and mesoderm formation
In Situ Hybridization/methods
T-Box Domain Proteins/genetics
Mesoderm
Cytochrome P-450 Enzyme System
Cytochrome P-450
Receptors
Paired Box Transcription Factors
Receptor
Notch1
In Situ Hybridization
Aldehyde Oxidoreductases/genetics
Receptors
Notch
Receptor
EphA4
Gene Expression Regulation
Developmental
Clock and wavefront model
Heart
Anatomy
GATA3 Transcription Factor/genetics/metabolism
Mesoderm/cytology/*metabolism
Aldehyde Oxidoreductases
Notch/genetics
Enzyme System/genetics
Cell biology
medicine.anatomical_structure
embryonic structures
Myogenic Regulatory Factor 5
Intermediate mesoderm
Receptor
animal structures
Transcription Factors/genetics
GATA3 Transcription Factor
Paired Box Transcription Factors/genetics
Biology
Glycosyltransferases/genetics
medicine
Paraxial mesoderm
Animals
Body Patterning
Homeodomain Proteins
Muscle Development/*genetics
Myocardium
Lateral plate mesoderm
Twist-Related Protein 1
Biomedical Sciences
Glycosyltransferases
EphA4/genetics
Notch1/genetics
Somite
Developmental/genetics
Gene Expression Regulation
Twist Transcription Factor/genetics
Body/Patterning/genetics
FacialMuscles/embryology/*metabolism
Myogenic Regulatory Factor 5/genetics
Homeodomain Proteins/genetics
T-Box Domain Proteins
NODAL
Head
Heart/embryology
Transcription Factors
Developmental Biology
Zdroj: Bothe, I & Dietrich, S 2006, ' The molecular setup of the avian head mesoderm and its implication for craniofacial myogenesis ', Developmental Dynamics, vol. 235, no. 10, pp. 2845-60 . https://doi.org/10.1002/dvdy.20903
ISSN: 1058-8388
DOI: 10.1002/dvdy.20903
Popis: The head mesoderm is the mesodermal tissue on either side of the brain, from forebrain to hindbrain levels, and gives rise to the genuine head muscles. Its relatedness to the more posterior paraxial mesoderm, the somites, which generate the muscles of the trunk, is conversely debated. To gain insight into the molecular setup of the head mesoderm, its similarity or dissimilarity to the somitic mesoderm, and the implications of its setup for the progress of muscle formation, we investigated the expression of markers (1) for mesoderm segmentation and boundary formation, (2) for regional specification and somitogenesis and (3) for the positive and negative control of myogenic differentiation. We show that the head mesoderm is molecularly distinct from somites. It is not segmented; even the boundary to the first somite is ill-defined. Importantly, the head mesoderm lacks the transcription factors driving muscle differentiation while genes suppressing differentiation and promoting cell proliferation are expressed. These factors show anteroposteriorly and dorsoventrally regionalised but overlapping expression. Notably, expression extends into the areas that actively contribute to the heart, overlapping with the expression of cardiac markers.
Databáze: OpenAIRE
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