Heart rate variability as predictor of mortality in sepsis: A prospective cohort study
| Autor: | José Luiz Padilha da Silva, Marcos Roberto de Sousa, Vandack Nobre, Fábio M. de Castilho, Antonio Luiz Pinho Ribeiro |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pulmonology lcsh:Medicine 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Severity of Illness Index Nervous System Mathematical and Statistical Techniques 0302 clinical medicine Heart Rate Medicine and Health Sciences Medicine Heart rate variability Prospective Studies lcsh:Science Prospective cohort study Aged 80 and over Multidisciplinary APACHE II Hazard ratio Middle Aged Prognosis Intensive Care Units Predictive value of tests Physical Sciences Cardiology Female SOFA score Anatomy Statistics (Mathematics) Research Article circulatory and respiratory physiology Adult medicine.medical_specialty Autonomic Nervous System Research and Analysis Methods Cardiologia 03 medical and health sciences Signs and Symptoms Predictive Value of Tests Diagnostic Medicine Sepsis Internal medicine Severity of illness Humans Statistical Methods Risk factor Aged Heart Failure business.industry lcsh:R Biology and Life Sciences 030208 emergency & critical care medicine Renal System Surgery Frequência cardíaca Respiratory Infections Electrocardiography Ambulatory Time Domain Analysis lcsh:Q business Mathematical Functions Mathematics Forecasting |
| Zdroj: | PLoS ONE, Vol 12, Iss 6, p e0180060 (2017) PLoS ONE Repositório Institucional da UFMG Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
| ISSN: | 1932-6203 |
| Popis: | Background Sepsis is a serious medical condition with increasing prevalence and high mortality. The role of the autonomic nervous system in pathophysiology of sepsis has been increasingly researched. The objective of this study is to evaluate the Heart rate variability (HRV) as a predictor of mortality in septic patients. Methods This was a prospective cohort of patients diagnosed with sepsis. Patient recruitment was carried out at ICU in tertiary university hospital between March 2012 and February 2014. Clinical data and laboratory exams were collected at admission. Each patient underwent a 20-minute Holter and a 24-hour Holter on the first day of enrollment. The primary outcome was the 28-day all-cause mortality. Results A total of 63 patients were included. Patients were categorized into nonsurvivor group (n = 16) or survivor group (n = 47) depending on this endpoint. Survivors were younger (48.6 years vs. 63.0 years), had better renal function and lower values in severity scores (APACHE II and SOFA) compared to nonsurvivors. In the 20-minute Holter, SDNN, Total Power, VLF Power, LF Power and LF/HF of nonsurvivors were significantly lower than those of survivors (p = |
| Databáze: | OpenAIRE |
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