The Gene Encoding the Oligodendrocyte-Myelin Glycoprotein Is Embedded within the Neurofibromatosis Type 1 Gene
| Autor: | David Viskochil, Gangfeng Xu, Ray White, John C. Carey, Peter O'Connell, Richard M. Cawthon, Melanie Culver, Jeff Stevens |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Neurofibromatosis 1 Molecular Sequence Data Restriction Mapping Nerve Tissue Proteins Locus (genetics) Biology GPI-Linked Proteins Translocation Genetic Cell Line Complementary DNA Humans Genomic library Amino Acid Sequence Cloning Molecular Molecular Biology Gene Gene Library Genetics Membrane Glycoproteins Base Sequence Nucleic acid sequence Intron Cell Biology Biological Evolution Molecular biology Introns Myelin-Associated Glycoprotein Oligodendrocyte-Myelin Glycoprotein genomic DNA Chromosomes Human Pair 1 Child Preschool Female Myelin-Oligodendrocyte Glycoprotein Myelin Proteins Chromosomes Human Pair 17 Research Article |
| Zdroj: | Molecular and Cellular Biology. 11:906-912 |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.11.2.906-912.1991 |
| Popis: | In the course of efforts to identify the neurofibromatosis type 1 gene (NF1), three genes were found embedded within an intron of NF1. The cDNA sequence of one of these genes (OMGP) encodes oligodendrocyte-myelin glycoprotein. OMGP spans at least 2.7 kb of genomic DNA, and it maps within 4 kb of the breakpoint of a balanced chromosomal translocation carried by an individual with NF1. OMGP is similar in genomic structure to two other expressed genes, EVI2A and EVI2B, which lie approximately 20 and 5 kb telomeric of the OMGP locus, respectively. All three genes have the same transcriptional orientation and are contained within one intron of NF1, which is transcribed off the opposite strand. Whether altered expression of OMGP might play a role in the clinical heterogeneity of NF1 is as yet unclear. |
| Databáze: | OpenAIRE |
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