Evidence for functional, inhibitory, histamine H3 receptors in rat carotid body Type I cells
| Autor: | Christopher N. Wyatt, Keith Troche, Carrie M. Thompson, Barbara L. Barr, Heidi L. Jordan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Histamine H1 receptor In Vitro Techniques Muscarinic Agonists Biology Receptors Presynaptic Histamine Agonists Rats Sprague-Dawley chemistry.chemical_compound Histamine H2 receptor Internal medicine Muscarinic acetylcholine receptor medicine Animals Receptors Histamine H3 Calcium Signaling Methacholine Chloride Acetylcholine receptor Carotid Body General Neuroscience Rats Endocrinology medicine.anatomical_structure Animals Newborn chemistry Carotid body Histamine H3 receptor Neuroscience Histamine Acetylcholine medicine.drug |
| Zdroj: | Neuroscience Letters. 471:15-19 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2009.12.077 |
| Popis: | The Type I cells are the sensory elements of the carotid bodies and play a critical role in defining the ventilatory response to hypoxia and hypercapnia. Type I cells release multiple neurotransmitters during a chemosensory stimulus resulting in increased firing of the carotid sinus nerve and modification of the breathing pattern. While much is known about the actions of individual neurotransmitters in this system, very little is known about how multiple neurotransmitters may integrate to shape the output of the carotid body. Recent data has indicated that the neurotransmitter histamine does not excite isolated Type I cells despite being released during hypoxia and its receptors being present on the Type I cells. Here the hypothesis that histamine might modulate an excitatory neurotransmitter such as acetylcholine was tested. Using calcium imaging techniques it was found that histamine attenuated calcium signaling events initiated by the muscarinic acetylcholine receptor agonist acetyl-β-methylcholine via an H3 receptor mediated mechanism. In summary, these results suggest that when acetylcholine and histamine are co-released from Type I cells in response to chemostimuli, histamine may attenuate or modulate the excitatory presynaptic actions of acetylcholine. |
| Databáze: | OpenAIRE |
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