AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents
| Autor: | György Trencsényi, Giovanni B. Giovenzana, Gábor Nagy, Fulvio Uggeri, Roberto Negri, Zsolt Baranyai, Imre Tóth, Dezső Szikra, Arianna Maria Giani, Silvio Aime, Ildikó Garai, Anikó Fekete, Norberto Masciocchi, Alessandro Maiocchi |
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| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry kinetics PET radiopharmaceuticals scandium thermodynamics technology industry and agriculture General Medicine Orvostudományok General Chemistry Pet imaging Conjugated system Klinikai orvostudományok 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Organic chemistry Chelation |
| Zdroj: | Angewandte Chemie International Edition. 56:2118-2122 |
| ISSN: | 1433-7851 |
| Popis: | Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44Sc(AAZTA)− chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator. |
| Databáze: | OpenAIRE |
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