SYNTHESIS AND BIOLOGICAL ACTIVITIES OF TWO ACTH-ANALOGUES CONTAINING L-NORARGININE IN POSITION 8
| Autor: | J.W. Van Nispen, G. I. Tesser, Rutger J. F. Nivard |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Arginine Tetrapeptide Stereochemistry Chemistry Molecular Conformation Biological activity Peptide Biochemistry Structure-Activity Relationship chemistry.chemical_compound Adrenocorticotropic Hormone Amide Side chain Structure–activity relationship Amino Acid Sequence Peptide sequence |
| Zdroj: | International Journal of Peptide and Protein Research. 9:193-202 |
| ISSN: | 0367-8377 |
| DOI: | 10.1111/j.1399-3011.1977.tb03481.x |
| Popis: | Two new ACTH-analogues, an octadecapeptide amide and a tetracosapeptide containing the lower homologue of arginine (norarginine) in position 8, have been synthesized by the generally accepted method. Special attention was paid to the synthesis of the required tetrapeptide representing the 7-10 sequence, which was obtained either by direct introduction of L-nitronorarginine or by amidination of the gamma-amino function in a protected peptide containing alpha, gamma-diaminobutyric acid. Biological activity determination showed that the shortening e arginine side chain in position 8 results in the formation of active ACTH-analogues. |
| Databáze: | OpenAIRE |
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