Molecular characteristics of H9N2 influenza viruses isolated from farmed raccoon dogs and arctic foxes in China
| Autor: | Shijin Jiang, Shi Wen-jian, Li JianLiang, Xie Zhi-jing, Zhu Qian, Guo Shou-yu, Yuan Peng, Zhang Feng-xia |
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| Rok vydání: | 2020 |
| Předmět: |
Male
China 040301 veterinary sciences animal diseases Zoology Foxes Biology medicine.disease_cause 0403 veterinary science 03 medical and health sciences Orthomyxoviridae Infections parasitic diseases Influenza A virus medicine Influenza A Virus H9N2 Subtype Animals Gene Phylogeny 030304 developmental biology 0303 health sciences General Veterinary Phylogenetic tree Intermediate host virus diseases 04 agricultural and veterinary sciences Raccoon Dogs Arctic Female geographic locations |
| Zdroj: | Research in veterinary science. 135 |
| ISSN: | 1532-2661 |
| Popis: | In this study, eight H9N2 IAVs were isolated from infected diseased, farmed raccoon dogs and arctic foxes. Eight genes shared 98.6%-100% identity among the isolates possessing a PSRSSR/GL motif at the HA cleavage site, which is same as the motif of G1 and Y280 lineages of H9N2 IAVs. The phylogenetic analysis showed that the HA genes of the eight isolates clustered with Y280-like viruses, whereas the NA genes belonged to F/98-like sublineage. Interestingly, the NS, NP, PB2 and PA genes of the isolates were closely related to H7N9 IAVs. This is the first evidence for isolation of H9N2 IAVs from raccoon dogs and arctic foxes. Raccoon dogs and arctic foxes potentially serve as an intermediate host for influenza viruses with pandemic potential toward other animals due to co-expression of both SA α-2,6-Gal and SA α-2,3-Gal receptors in a wide range of their tissues. |
| Databáze: | OpenAIRE |
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