New antisickling agent 3,4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid
| Autor: | Koji Nakanishi, Joseph I. Okogun, Clayton Natta, V. U. Enyenihi, D.E.U. Ekong, Valeria Balogh-Nair |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
Erythrocytes Multidisciplinary Hemoglobin Sickle Cell Erythrocytes Abnormal Male mice Anemia Sickle Cell Pharmacology Acute toxicity Benzopyran Oxygen Butyric acid Mice chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry visual_art medicine visual_art.visual_art_medium Animals Benzopyrans Bark |
| Zdroj: | Nature. 258:743-746 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/258743a0 |
| Popis: | RECENT efforts to develop therapeutic agents for the treatment of sickle cell disease have led to the discovery of several antisickling agents1. We now report a new such agent, 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-butyric acid (DBA) (Compound 1). This compound efficiently prevents and reverses sickling, and has no acute toxicity in male mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|