Immunological and Virological Impact of Highly Active Antiretroviral Therapy Initiated during Acute HIV‐1 Infection
| Autor: | Juergen K. Rockstroh, Ingrid Stahmer, Hendrik Streeck, Xiaojiang Gao, Jan van Lunzen, Heiko Jessen, Mathias Lichterfeld, Marcus Altfeld, Michael T. Waring, Bruce D. Walker, Galit Alter, Todd M. Allen, Arne Jessen, Mary Carrington, Nickolas Teigen |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Time Factors T cell HIV Infections Viremia CD8-Positive T-Lymphocytes Virus Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active medicine Humans Immunology and Allergy Prospective Studies Sida biology virus diseases medicine.disease biology.organism_classification Virology CD4 Lymphocyte Count Infectious Diseases medicine.anatomical_structure Anti-Retroviral Agents Acute Disease Immunology Lentivirus HIV-1 RNA Viral Viral disease CD8 |
| Zdroj: | The Journal of Infectious Diseases. 194:734-739 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/503811 |
| Popis: | The immunological and virological impact of short-term treatment initiated during acute human immunodeficiency virus type 1 (HIV-1) infection was assessed prospectively in 20 subjects, 12 of whom initiated highly active antiretroviral therapy (HAART) for 24 weeks and then terminated treatment. Treatment resulted in suppression of viremia, an increase in the CD4 + T cell count, enhanced differentiation of HIV-1-specific CD8 + T cells from effector memory to effector cells at week 24 of HAART, and significantly higher virus-specific interferon-γ + CD8 + T cell responses after viral rebound (at week 48). However, despite these immunological changes, no differences in viremia or in the CD4 + T cell count were found 6 months after HAART was stopped, when treated subjects were compared with untreated subjects. |
| Databáze: | OpenAIRE |
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