Polypharmacy in older adults with human immunodeficiency virus infection compared with the general population
| Autor: | María José Rabanaque-Hernández, Vicente Compaired-Turlán, Mercedes Gimeno-Gracia, María José Crusells-Canales, Francisco Javier Armesto-Gómez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Male Pathology medicine.medical_specialty media_common.quotation_subject 030106 microbiology Population Human immunodeficiency virus (HIV) HIV Infections Comorbidity medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Sex Factors Internal medicine Medicine Humans 030212 general & internal medicine education media_common Original Research Aged Polypharmacy education.field_of_study business.industry aging General Medicine Middle Aged HIV infection Drug class Defined daily dose Therapy medication Concomitant Clinical Interventions in Aging Female Geriatrics and Gerontology business |
| Zdroj: | Clinical Interventions in Aging Zaguán. Repositorio Digital de la Universidad de Zaragoza instname |
| ISSN: | 1178-1998 |
| Popis: | Mercedes Gimeno-Gracia,1 María José Crusells-Canales,2 Francisco Javier Armesto-Gómez,3 Vicente Compaired-Turlán,4 María José Rabanaque-Hernández5 1Pharmacy Department, Lozano Blesa University Clinical Hospital, Aragon Institute for Health Research, 2Department of Infectious Diseases, Aragon Institute for Health Research, Lozano Blesa University Clinical Hospital, 3Pharmacy Department, Aragon Health Service, 4Pharmacy Department, Lozano Blesa University Clinical Hospital, 5Department of Public Health, University of Zaragoza, Zaragoza, Spain Background: The percentage of older HIV-positive patients is growing, with an increase in age-related comorbidities and concomitant medication. Objectives: To quantify polypharmacy and profile types of non-antiretroviral drugs collected at community pharmacies in 2014 by HIV-positive individuals on antiretroviral therapy and to compare these findings with those of the general population. Methods: HIV-positive patients (n=199) were compared with a group of patients from the general population (n=8,172), aged between 50 and 64 years. The factors compared were prevalence of polypharmacy (≥5 comedications with cumulative defined daily dose [DDD] per drug over 180), percentage of patients who collected each therapeutic class of drug, and median duration for each drug class (based on DDD). Results were stratified by sex. Results: Polypharmacy was more common in HIV-positive males than in the male general population (8.9% vs 4.4%, P=0.010). Polypharmacy was also higher in HIV-positive females than in the female general population (11.3% vs 3.4%, P=0.002). Percentage of HIV-positive patients receiving analgesics, anti-infectives, gastrointestinal drugs, central nervous system (CNS) agents, and respiratory drugs was higher than in the general population, with significant differences between male populations. No differences were observed in proportion of patients receiving cardiovascular drugs. The estimated number of treatment days (median DDDs) were higher in HIV-positive males than in males from the general population for anti-infectives (32.2 vs 20.0, P |
| Databáze: | OpenAIRE |
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