L-NG-nitro-arginine inhibits nicotine-induced relaxation of isolated rat duodenum
| Autor: | Nomoto Teruko, Furukawa Kyoko, Irie Kaoru, Muraki Takamura |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Nicotine Arginine Duodenum Calcitonin Gene-Related Peptide Muscle Relaxation Endogeny Hexamethonium Compounds Tetrodotoxin In Vitro Techniques Nitroarginine Nitric oxide chemistry.chemical_compound Adenosine Triphosphate Internal medicine medicine Animals Thyrotropin-Releasing Hormone Pharmacology Adenine Nucleotides musculoskeletal neural and ocular physiology Muscle Smooth Rats Inbred Strains musculoskeletal system Adenosine Rats Endocrinology medicine.anatomical_structure chemistry Mechanism of action Calcitonin cardiovascular system medicine.symptom tissues medicine.drug |
| Zdroj: | European journal of pharmacology. 202(2) |
| ISSN: | 0014-2999 |
| Popis: | We studied the effects of L-N G -nitro-arginine (L-NOARG), which inhibits nitric oxide (NO) biosynthesis from L-arginine, on the non-adrenergic, non-cholinergic (NANC)-mediated relaxation induced by nicotine in isolated rat duodenum. L-NOARG reduced nicotine-induced relaxation, and L-arginine prevented the inhibitory effect of L-NOARG. However, L-NOARG did not inhibit the tetrodotoxin-insensitive relaxation induced by adenosine 5′-triphosphate, α,β-methyleneadenosine 5′-triphosphate, thyrotropin-releasing hormone or the calcitonin gene-related peptide. Endogenous NO thus could possibly be involved in the NANC-mediated relaxation of rat duodenum induced by nicotine. |
| Databáze: | OpenAIRE |
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