Carcinoma Showing Thymus-Like Differentiation (CASTLE) Arising in the Sublingual Gland
| Autor: | Simonetta Battocchio, Davide Lombardi, Roberto Maroldi, Fabio Facchetti, Piero Nicolai, Michele Tomasoni, Laura Ardighieri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty medicine.medical_treatment salivary glands Biopsy Fine-Needle Neck mass Submucosal Lesion Pathology and Forensic Medicine Diagnosis Differential Lesion 03 medical and health sciences 0302 clinical medicine sublingual gland Carcinoma Humans Medicine carcinoma showing thymus-like differentiation business.industry Thyroid CASTLE Sublingual Gland Neoplasms Sublingual gland Neck dissection medicine.disease Magnetic Resonance Imaging Primary tumor 030104 developmental biology medicine.anatomical_structure Lymphatic Metastasis Positron-Emission Tomography 030220 oncology & carcinogenesis Neck Dissection Radiotherapy Adjuvant Surgery Lymph Nodes Anatomy medicine.symptom business |
| Popis: | Carcinoma showing thymic-like differentiation (CASTLE) is a rare tumor most commonly occurring in the thyroid and soft tissues of the neck. We report the first case of CASTLE occurring in the sublingual gland. The patient, a 35-year-old healthy man, presented with a submucosal lesion located in the anterior right floor of the oral cavity and an ipsilateral neck mass. The lesion had been previously investigated by neck computed tomography and ultrasound-guided fine needle aspiration cytology and diagnosed as metastatic squamous cell carcinoma. After oral cavity magnetic resonance imaging, positron emission tomography, and a non-diriment, fine needle aspiration cytology of the sublingual mass, the patient was treated as affected by a sublingual gland malignancy with removal of primary tumor and neck dissection. Morphological and immunohistochemical findings were diagnostic for primary sublingual gland CASTLE. The patient received adjuvant radiotherapy and is free of disease 2 years after treatment. We describe the pathological features of the lesion and discuss the possible differential diagnoses. |
| Databáze: | OpenAIRE |
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