Oesophageal motility in adult coeliac disease
| Autor: | A Plesa, P. Usai Satta, Angelo Balestrieri, F Boy, M.V. Cherchi, Gabrio Bassotti, Paolo Usai, Antonio Morelli |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Manometry Disease Gastroenterology Oesophageal motility Sprue law.invention Randomized controlled trial law Internal medicine Surveys and Questionnaires medicine Humans Esophageal Motility Disorders Pathological Endocrine and Autonomic Systems business.industry Reflux nutritional and metabolic diseases Hydrogen-Ion Concentration Dysphagia digestive system diseases Clinical trial Celiac Disease Female medicine.symptom business |
| Zdroj: | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 7(4) |
| ISSN: | 1350-1925 |
| Popis: | Coeliac sprue is a relatively frequent disease with protean clinical manifestations. Recent studies suggest that gastrointestinal motor abnormalities may explain some symptoms complained of by such patients. We investigated whether coeliac patients have oesophageal motor abnormalities from both a clinical and a physiological point of view. Thirty-six consecutive adult sprue subjects (14 during the florid phase and 22 on gluten-free diet) were studied. A clinical questionnaire on gastrointestinal symptoms (with emphasis on those of oesophageal origin) was administered. Moreover, 18 patients (13 on free and five on gluten-free diet) gave their consent for oesophageal manometry and eight subjects for pH-metry also. Oesophageal clinical symptoms were compared with those of 144 age- and sex-matched controls from a general population sample, and manometry with that of 34 healthy volunteers. Of coeliac patients 50% complained of dysphagia (P0.001 vs. controls) and 14% noncardiac chest pain (P = NS vs. controls). Manometric examination showed motor abnormalities in 67% of the subjects examined, consisting of nutcracker oesophagus, hypotonic lower oesophageal sphincter associated with simultaneous contractions, and frequent repetitive (3 peaks) contractions. These abnormalities were equally distributed among free and gluten-free diet patients. pH-metry showed only one pathological reflux out of eight subjects studied. We conclude that patients with coeliac sprue may display abnormal oesophageal motility. This confirms previous studies suggesting that gastrointestinal motor abnormalities should probably be added to the clinical spectrum of the disease. |
| Databáze: | OpenAIRE |
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