A murine model of targeted infusion for intracranial tumors
| Autor: | Joseph J. Skitzki, Tara A. Barone, Chandler Wilfong, Anatoli S. Gleiberman, Julie A. Alosi, Natalia Fedtsova, Robert J. Plunkett, Andrei V. Gudkov, Minhyung Kim |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Pathology Mice Nude Antineoplastic Agents Tumor response Article Cell Line Mice 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Internal medicine medicine.artery Glial Fibrillary Acidic Protein medicine Animals Humans Infusions Intra-Arterial Neurologic Examination Brain Neoplasms business.industry Brain Drug administration medicine.disease Xenograft Model Antitumor Assays Disease Models Animal Neurology Novel agents Murine model 030220 oncology & carcinogenesis Drug delivery Neurology (clinical) Internal carotid artery Glioblastoma business 030217 neurology & neurosurgery Large animal |
| Zdroj: | Journal of Neuro-Oncology. 126:37-45 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-015-1942-7 |
| Popis: | Historically, intra-arterial (IA) drug administration for malignant brain tumors including glioblastoma multiforme (GBM) was performed as an attempt to improve drug delivery. With the advent of percutaneous neuorovascular techniques and modern microcatheters, intracranial drug delivery is readily feasible; however, the question remains whether IA administration is safe and more effective compared to other delivery modalities such as intravenous (IV) or oral administrations. Preclinical large animal models allow for comparisons between treatment routes and to test novel agents, but can be expensive and difficult to generate large numbers and rapid results. Accordingly, we developed a murine model of IA drug delivery for GBM that is reproducible with clear readouts of tumor response and neurotoxicities. Herein, we describe a novel mouse model of IA drug delivery accessing the internal carotid artery (ICA) to treat ipsilateral implanted GBM tumors that is consistent and reproducible with minimal experience. The intent of establishing this unique platform is to efficiently interrogate targeted anti-tumor agents that may be designed to take advantage of a directed, regional therapy approach for brain tumors. |
| Databáze: | OpenAIRE |
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