Prediction of Core Signaling Pathway by Using Diffusion- and Perfusion-based MRI Radiomics and Next-generation Sequencing in Isocitrate Dehydrogenase Wild-type Glioblastoma
| Autor: | Seo Young Park, Youngheun Jo, Soo Jung Nam, Ho Sung Kim, Jeong Hoon Kim, Sung-Min Chun, Ji Eun Park |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Computational biology DNA sequencing 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Radiomics Medicine Humans Radiology Nuclear Medicine and imaging Personalized therapy Retrospective Studies business.industry Brain Neoplasms Wild type Brain High-Throughput Nucleotide Sequencing Middle Aged medicine.disease Isocitrate Dehydrogenase Isocitrate dehydrogenase Diffusion Magnetic Resonance Imaging 030220 oncology & carcinogenesis Female Signal transduction business Glioblastoma Perfusion Magnetic Resonance Angiography Signal Transduction |
| Zdroj: | Radiology. 294(2) |
| ISSN: | 1527-1315 |
| Popis: | Background Next-generation sequencing (NGS) enables highly sensitive cancer genomics analysis, but its clinical implications for therapeutic options from imaging-based prediction have been limited. Purpose To predict core signaling pathways in isocitrate dehydrogenase (IDH) wild-type glioblastoma by using diffusion and perfusion MRI radiomics and NGS. Materials and Methods The radiogenomics model was developed by using retrospective patients with glioma who underwent NGS and anatomic, diffusion-, and perfusion-weighted imaging between March 2017 and February 2019. For testing model performance in predicting core signaling pathway, patients with IDH wild-type glioblastoma from a retrospective analysis from a registry ( |
| Databáze: | OpenAIRE |
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