Prevalence of non-alcoholic fatty liver and liver fibrosis in patients with moderate-severe psoriasis: A cross-sectional cohort study
| Autor: | Cristian Valenzuela-Oñate, Moisés Diago-Madrid, J.M. Ortiz-Salvador, Marta García-Legaz-Martínez, José Luis Sánchez-Carazo, Juan José Tamarit-García, Miriam Alonso‐Carpio, Amparo Pérez-Ferriols, Álvaro Martínez-Doménech, Jorge Magdaleno-Tapial |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Dermatology Gastroenterology Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences Liver disease 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine Psoriasis medicine Humans Metabolic Syndrome business.industry Fatty liver Middle Aged medicine.disease Cross-Sectional Studies 030220 oncology & carcinogenesis Cohort Elasticity Imaging Techniques Female Metabolic syndrome Steatosis business Dyslipidemia Cohort study |
| Zdroj: | The Australasian journal of dermatologyReferences. 61(2) |
| ISSN: | 1440-0960 |
| Popis: | Background/objectives Several studies have reported that non-alcoholic fatty liver disease (NAFLD) is more frequent in patients with psoriasis, but few have reviewed the presence of liver fibrosis in those patients. Methods Cross-sectional cohort, single-centre study, continuously selecting all patients with moderate-severe psoriasis seen at the Psoriasis Unit of a Tertiary Hospital. The grade of liver steatosis was assessed using liver ultrasound, and the quantity of liver fibrosis was graded using a transitional vibration-controlled elastography (Fibroscan®). Results A total of 71 patients (66.2% male) were included, with an average age of 46.6 years old. The maximum historical PASI average was 14.4 while the baseline PASI average at the time of the study was 2. A third (36%) of patients met the criteria for metabolic syndrome 52% of patients had steatosis; being male, having metabolic syndrome comorbidities, elevated AST/ALT enzymes, dyslipidemia and high initial PASI were significantly related. 14% of patients had moderate liver fibrosis (≥7.6 KPa). In 30% of them, no ultrasound liver steatosis was observed. Conclusions Elastography may be a useful tool along with ultrasound to evaluate liver disease in patients with psoriasis. |
| Databáze: | OpenAIRE |
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