Effects of dextromethorphan on MDMA-induced serotonergic aberration in the brains of non-human primates using [123I]-ADAM/SPECT
| Autor: | Kang Wei Chang, Kuo-Hsing Ma, Wen Sheng Huang, Mei Hsiu Liao, Shao-Ju Weng, Te Hung Hsu, Tsung Ta Liu, Chi Chang Sung, Chien-Fu F. Chen, Cheng Yi Cheng, Yuahn-Sieh Huang, Sheau Huei Chueh |
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| Rok vydání: | 2016 |
| Předmět: |
Primates
0301 basic medicine Serotonin Time Factors N-Methyl-3 4-methylenedioxyamphetamine Striatum Pharmacology Serotonergic Dextromethorphan Article Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine mental disorders Radioligand Animals Medicine Tomography Emission-Computed Single-Photon Multidisciplinary business.industry Cinanserin Neurotoxicity Brain MDMA medicine.disease Magnetic Resonance Imaging 030104 developmental biology business psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep38695 |
| Popis: | 3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known to cause serotonergic neurotoxicity in the brain. Dextromethorphan (DM) is a widely used antitussive reported to exert anti-inflammatory effect in vivo. In this study, we examined the long-term effect of MDMA on the primate serotonergic system and the protective property of DM against MDMA-induced serotonergic abnormality using single photon emission computed tomography (SPECT). Nine monkeys (Macaca cyclopis) were divided into three groups, namely control, MDMA and co-treatment (MDMA/DM). [123I]-ADAM was used as the radioligand for serotonin transporters (SERT) in SPECT scans. SERT levels of the brain were evaluated and presented as the uptake ratios (URs) of [123I]-ADAM in several regions of interest of the brain including midbrain, thalamus and striatum. We found that the URs of [123I]-ADAM were significantly lower in the brains of MDMA than control group, indicating lower brain SERT levels in the MDMA-treated monkeys. This MDMA-induced decrease in brain SERT levels could persist for over four years. However, the loss of brain SERT levels was not observed in co-treatment group. These results suggest that DM may exert a protective effect against MDMA-induced serotonergic toxicity in the brains of the non-human primate. |
| Databáze: | OpenAIRE |
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