Identification of blood vascular endothelial stem cells by the expression of protein C receptor
| Autor: | Yi Arial Zeng, Daisong Wang, Wenqian Song, Qing Cissy Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
mammary gland Endothelium Angiogenesis bipotent Biology 03 medical and health sciences Vasculogenesis lineage tracing medicine Procr Progenitor cell Molecular Biology vascular endothelial stem cell Endothelial protein C receptor Stem Cells Mesenchymal stem cell Endothelial Cells Endothelial Protein C Receptor Cell Biology Cell biology Endothelial stem cell 030104 developmental biology medicine.anatomical_structure Immunology Original Article Stem cell Pericytes |
| Zdroj: | Cell Research |
| ISSN: | 1748-7838 1001-0602 |
| Popis: | Vascular growth and remodeling are dependent on the generation of new endothelial cells from stem cells and the involvement of perivascular cells to maintain vessel integrity and function. The existence and cellular identity of vascular endothelial stem cells (VESCs) remain unclear. The perivascular pericytes in adult tissues are thought to arise from the recruitment and differentiation of mesenchymal progenitors during early development. In this study, we identified Protein C receptor-expressing (Procr+) endothelial cells as VESCs in multiple tissues. Procr+ VESCs exhibit robust clonogenicity in culture, high vessel reconstitution efficiency in transplantation, long-term clonal expansion in lineage tracing, and EndMT characteristics. Moreover, Procr+ VESCs are bipotent, giving rise to de novo formation of endothelial cells and pericytes. This represents a novel origin of pericytes in adult angiogenesis, reshaping our understanding of blood vessel development and homeostatic process. Our study may also provide a more precise therapeutic target to inhibit pathological angiogenesis and tumor growth. |
| Databáze: | OpenAIRE |
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