Coronarotropic properties of cyclic GABA derivative TZ-146

Autor:	D. V. Sirotenko, Yu. R. Sheikh-Zade, A. V. Uvarov, I. L. Cherednik, P. B. Popov, P. A. Galenko-Yaroshevskii
Rok vydání:	1999
Předmět:	medicine.medical_specialty CATS Chemistry medicine.medical_treatment Adenylate kinase General Medicine Blood flow Vagotomy Cyclase General Biochemistry Genetics and Molecular Biology gamma-Aminobutyric acid Endocrinology Internal medicine medicine Strophanthin Reactive hyperemia medicine.drug
Zdroj:	Scopus-Elsevier
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02433827
Popis:	In the experiments on isolated contracting, fibrillating, and strophanthin K-arrested cat hearts, TZ-146, cyclic derivative of gamma aminobutyric acid enhanced the outflow of perfusate. When testedin vivo, this preparation increased the indices of phasic coronary blood flow in dogs, surpassing the effects of reactive hyperemia, which characterizes the dilatory capacity of coronary vessels. Pharmacological analysis and experiments with bilateral vagotomy in cats and dogs suggest that coronarotropic effects of TZ-146 can result from activation of adenylate cyclase and accumulation of cAMP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881c0aa30d2e5bd35c00baeddeea4833 https://doi.org/10.1007/bf02433827 Zobrazit plný text záznamu Full text from SpringerLink