Fabrication andin vitro characterization of three-dimensional organic/inorganic scaffolds by robocasting

Autor: Eduardo Saiz, Antoni P. Tomsia, Karol Gryn, Ravi K. Nalla, Julie Russias, Gao Liu, Sylvain Deville
Přispěvatelé: Laboratoire de Synthèse et Fonctionnalisation de Céramiques (LSFC), Saint Gobain-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2007
Předmět:
Ceramics
Materials science
Compressive Strength
Polyesters
Simulated body fluid
Composite number
Biomedical Engineering
FOS: Physical sciences
Biocompatible Materials
Applied Physics (physics.app-ph)
02 engineering and technology
Apatite
[SPI.MAT]Engineering Sciences [physics]/Materials
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Tissue engineering
Hardness
Humans
Transition Temperature
Ceramic
Composite material
Porosity
030304 developmental biology
chemistry.chemical_classification
Condensed Matter - Materials Science
0303 health sciences
Metals and Alloys
Materials Science (cond-mat.mtrl-sci)
Physics - Applied Physics
Robotics
[CHIM.MATE]Chemical Sciences/Material chemistry
Polymer
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Body Fluids
chemistry
visual_art
Polycaprolactone
Microscopy
Electron
Scanning
Ceramics and Composites
visual_art.visual_art_medium
Glass
0210 nano-technology
Zdroj: Journal of Biomedical Materials Research Part A
Journal of Biomedical Materials Research Part A, Wiley, 2007, 83A (2), pp.434-445. ⟨10.1002/jbm.a.31237⟩
ISSN: 1552-4965
1549-3296
Popis: A key issue for the fabrication of scaffolds for tissue engineering is the development of processing techniques flexible enough to produce materials with a wide spectrum of solubility (bioresorption rates) and mechanical properties matching those of calcified tissues. These techniques must also have the capability of generating adequate porosity to further serve as a framework for cell penetration, new bone formation, and subsequent remodeling. In this study, we show how hybrid organic/inorganic scaffolds with controlled microstructures can be built using robotic assisted deposition at room temperature. Polylactide or polycaprolactone scaffolds with pore sizes ranging between 200-500 {\mu}m and hydroxyapatite contents up to 70 wt % were fabricated. Compressive tests revealed an anisotropic behavior of the scaffolds, strongly dependent on their chemical composition. The inclusion of an inorganic component increased their stiffness but they were not brittle and could be easily machined even for ceramic contents up to 70 wt%. The mechanical properties of hybrid scaffolds did not degrade significantly after 20 days in simulated body fluid. However, the stiffness of pure polylactide scaffolds increased drastically due to polymer densification. Scaffolds containing bioactive glasses were also printed. After 20 days in simulated body fluid they developed an apatite layer on their surface.
Comment: 22 pages, 15 figures
Databáze: OpenAIRE
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