The effect of serum lipid regulation on the development of femoral atherosclerosis in hyperlipidaemia: a non-randomized controlled study
| Autor: | G. Ruhn, U. Erikson, A. G. Olsson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Very low-density lipoprotein Hyperlipoproteinemias Arteriosclerosis Cholesterol VLDL Blood Pressure Hyperlipidemias Femoral artery Asymptomatic Niacin chemistry.chemical_compound medicine.artery Internal medicine Internal Medicine medicine Humans Analysis of Variance Fenofibrate business.industry Cholesterol Smoking Middle Aged medicine.disease Combined Modality Therapy Lipids Diet Femoral Artery Radiography Endocrinology Atheroma Blood pressure chemistry Low-density lipoprotein Drug Evaluation lipids (amino acids peptides and proteins) medicine.symptom business medicine.drug |
| Zdroj: | Journal of internal medicine. 227(6) |
| ISSN: | 0954-6820 |
| Popis: | The development of femoral atheroma after 1 year of treatment with diet and nicotinic acid plus fenofibrate was studied in 45 asymptomatic, hyperlipidaemic, middle-aged male subjects in a non-randomized controlled study. The median serum very low density lipoprotein (VLDL) cholesterol concentration and the low density lipoprotein (LDL) cholesterol concentration were lowered by 67% and 36%, respectively, in the treatment group. The median serum high density lipoprotein (HDL) cholesterol concentration was increased by 23%. Femoral atheroma was estimated by overall atherosclerosis score (OAS). Changes in femoral atherosclerosis were estimated by intrapair comparison of angiograms. Progression was found in 24% and 40% in the treatment and control groups, respectively. Regression occurred in 29% and 0%, respectively. The OAS decrease correlated with reductions in VLDL cholesterol and systolic blood pressure. |
| Databáze: | OpenAIRE |
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