Effects of quinolone and poloxamer otic suspension on rat tympanic membranes
| Autor: | Patrick J. Antonelli, Carolyn O. Dirain |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Ofloxacin
Tympanic Membrane medicine.drug_class medicine.medical_treatment Poloxamer Quinolones 03 medical and health sciences 0302 clinical medicine Tympanic Membranes 030225 pediatrics otorhinolaryngologic diseases medicine Animals 030223 otorhinolaryngology Saline business.industry General Medicine Neomycin Quinolone Anti-Bacterial Agents Rats Ciprofloxacin Otorhinolaryngology Anesthesia Pediatrics Perinatology and Child Health Poloxamer 407 sense organs business medicine.drug |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 147:110805 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2021.110805 |
| Popis: | Commercial quinolone ear drops (0.3%) delivered twice daily for 10 days cause tympanic membrane perforations (TMPs) in rats. We aimed to evaluate if a single application of 6% quinolone in poloxamer causes TMPs in rats.Rats were randomized to 5 groups (10/group), with one ear receiving a single otic instillation of 16% poloxamer 407 or 188 (as found in a commercial otic preparation and a wound dressing), or ofloxacin, ciprofloxacin, or neomycin at 6% in suspension with 16% poloxamer 407. The contralateral ear received saline. Rats were assessed over 42 days.No TMPs were seen in ears treated with saline, poloxamer 407 or 188, or in ears treated with ofloxacin-, ciprofloxacin-, or neomycin-poloxamer suspension. White precipitates were observed on the canal or tympanic membrane of ciprofloxacin and ofloxacin-treated ears. Precipitates were more common in ciprofloxacin-treated ears until day 10 (p 0.0001 to p = 0.0004). Tympanic membrane surface irregularities, were also observed mostly in the ciprofloxacin-treated ears from day 3-42 (p = 0.03 to p = 0.0033).Quinolone in poloxamer otic preparations may be a safer therapeutic alternative to conventional quinolone ear drops in ears with intact TMs, particularly those felt to be at risk for developing TMPs. |
| Databáze: | OpenAIRE |
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