Inflammatory Cytokine Profiles During Exercise in Obese, Diabetic, and Healthy Children
| Autor: | Shirin Heydari, Pietro Galassetti, Milagros Ibardolaza, Andria M. Pontello, Jaime S. Rosa, Rebecca L. Flores, Stacy R. Oliver |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment blood [Cytokines] pediatric obesity 030209 endocrinology & metabolism chemokines Definitions 030204 cardiovascular system & hematology tumor necrosis factor-a Exercise challenge 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Medicine and Health Sciences T1DM Medicine Humans Obesity Exercise physiology Child blood [Diabetes Mellitus Type 1] Type 1 diabetes exercise business.industry Interleukin-6 medicine.disease blood [Obesity] Cytokine Diabetes Mellitus Type 1 Pediatrics Perinatology and Child Health Cytokines interleukin-2 Female business physiology [Exercise] |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology Rosa, Jaime S; Heydari, Shirin; Oliver, Stacy R; Flores, Rebecca L; Pontello, Andria M; Ibardolaza, Milagros; et al.(2011). Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children.. Journal of clinical research in pediatric endocrinology, 3(3), 115-121. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/15z289nz |
| ISSN: | 1308-5735 1308-5727 |
| Popis: | Objective: Modulation of inflammatory status is considered a key component of the overall health effects of exercise. This may be especially relevant in children with obesity (Ob) or type 1 diabetes (T1DM), in which an imbalance between pro- and anti-inflammatory mediators could accelerate onset and progression of cardiovascular complications. To date, exercise-induced alterations in immuno-modulatory mediators in Ob and T1DM children remain largely unknown. Methods: In this study, we monitored the kinetic profiles of 8 pro-and anti-inflammatory cytokines (TNF-a, IL-6, IL-2, IL-8, IL-5, IL-13, IL-10, IL-4) during a standardized exercise challenge (ten 2-min cycling bouts at 80% VO2max, separated by 1-min intervals) in 23 Ob (12 females, 11 males), 23 T1DM (10 females and 13 males) patients and 20 healthy (CL, 10 females and 10 males) children. Blood glucose of T1DM patients was kept in the 4.4-6.1 mM range for at least 90 minute prior to and during exercise. Blood samples were drawn at rest and after every other exercise bout. Results: In Ob, TNF-a and IL-2 were significantly greater (p |
| Databáze: | OpenAIRE |
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