Automated Synthesis of a Library of Triazolated 1,2,5-Thiadiazepane 1,1-Dioxides via a Double Aza-Michael Strategy

Autor:	Danse Bi, Gerald H. Lushington, Conrad Santini, Salim Javed, Patrick Porubsky, Benjamin Neuenswander, Michael G. Organ, David E. Hill, Qin Zang, Paul R. Hanson, Farman Ullah
Rok vydání:	2012
Předmět:	Aza Compounds Molecular Structure Combinatorial Chemistry Techniques Chemistry Stereochemistry Azepines General Chemistry General Medicine Combinatorial chemistry Article Cycloaddition Small Molecule Libraries Automation Sulfur
Zdroj:	ACS Combinatorial Science. 14:456-459
ISSN:	2156-8944 2156-8952
Popis:	The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88137e9713f100f9da0cbb06cb98cb7e https://doi.org/10.1021/co300049u Zobrazit plný text záznamu