The Effect of Corticosteroid Withdrawal on Glucose Metabolism and Anti-GAD Antibodies in Simultaneous Pancreas–Kidney Transplant Patients
| Autor: | María José Ricart, Enric Esmatjes, Marina Pontello Cristelli, Rogério Silicani Ribeiro, Antonio J. Amor, Joana Ferrer, Vanessa Guerrero |
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| Rok vydání: | 2016 |
| Předmět: |
Blood Glucose
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Context (language use) 030230 surgery Pancreas transplantation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Adrenal Cortex Hormones Internal medicine medicine Humans Insulin Autoantibodies Retrospective Studies Transplantation Type 1 diabetes business.industry medicine.disease Kidney Transplantation Discontinuation Diabetes Mellitus Type 1 Glucose Endocrinology chemistry Corticosteroid 030211 gastroenterology & hepatology Pancreas Transplantation Glycated hemoglobin business Follow-Up Studies |
| Zdroj: | Progress in Transplantation. 26:249-254 |
| ISSN: | 2164-6708 1526-9248 |
| DOI: | 10.1177/1526924816654371 |
| Popis: | Context:Corticosteroid withdrawal may reduce insulin resistance; however, it could also influence pancreatic autoantibody profile in simultaneous pancreas–kidney (SPK) transplant patients.Objective:To evaluate the effect of corticosteroid withdrawal on glucose metabolism and anti-glutamic acid decarboxylase (GAD) antibody titers in SPK patients with type 1 diabetes after 12 months of follow-up.Design:In this retrospective study, fasting glucose and glycated hemoglobin (A1c) were compared before and after 3, 6, and 12 months of corticosteroid withdrawal in 80 SPK patients. In addition, weight, anti-GAD, and C-peptide levels were compared before and after withdrawal. Finally, fasting and postglucose, insulin, and C-peptide levels were compared before and after withdrawal in 25 patients undergoing oral glucose tolerance test (OGTT).Results:Fasting glucose levels did not change during corticosteroid discontinuation. After 12 months, A1c slightly increased from 4.6% (0.4%) to 4.8% (0.6%) ( P < .01) and C-peptide decreased from 2.8 (1.1) ng/mL to 2.4 (1.3) ng/mL ( P Conclusion:Corticosteroid withdrawal has no significant effect on glucose metabolism and on anti-GAD profile among SPK patients. |
| Databáze: | OpenAIRE |
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