Revisiting the hallmarks of cancer: The role of hyaluronan
| Autor: | Arianna Parnigoni, Davide Vigetti, Elena Caravà, Ilaria Caon, Barbara Bartolini, Evgenia Karousou, Alberto Passi, Manuela Viola, Paola Moretto |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
HAS2-AS1
0301 basic medicine Cancer Research 4-Methylumbelliferone CD44 Extracellular matrix HAS2 Angiogenesis medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Cell Movement Neoplasms Tumor Microenvironment medicine Animals Humans Neoplasm Invasiveness Hyaluronic Acid Neoplasm Metastasis Tissue homeostasis Cell Proliferation Neovascularization Pathologic biology Cancer medicine.disease Extracellular Matrix Cell biology Cell Transformation Neoplastic 030104 developmental biology The Hallmarks of Cancer 030220 oncology & carcinogenesis biology.protein Tumor Escape Disease Susceptibility Energy Metabolism Carcinogenesis Reprogramming Signal Transduction |
| Zdroj: | Seminars in Cancer Biology. 62:9-19 |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2019.07.007 |
| Popis: | Extracellular matrix (ECM) is a complex network of macromolecules such as proteoglycans (PGs), glycosaminoglycans (GAGs) and fibrous proteins present within all tissues and organs. The main role of ECM is not only to provide an essential mechanical scaffold for the cells but also to mediate crucial biochemical cues that are required for tissue homeostasis. Dysregulations in ECM deposition alter cell microenvironment, triggering the onset or the rapid progression of several diseases, including cancer. Hyaluronan (HA) is a ubiquitous component of ECM considered as one of the main players of cancer initiation and progression. This review discusses how HA participate in and regulate several aspects of tumorigenesis, with particular attention to the hallmarks of cancer proposed by Hanahan and Weinberg such as sustaining of the proliferative signaling, evasion of apoptosis, angiogenesis, activation of invasion and metastases, reprogramming of energy metabolism and evasion of immune response. |
| Databáze: | OpenAIRE |
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