Establishment and Maintenance of the Macrophage Niche
| Autor: | Johnny Bonnardel, Marc Bajénoff, Guilhem R. Thierry, Martin Guilliams |
|---|---|
| Přispěvatelé: | Department of Biomedical Molecular Biology [Ghent], Universiteit Gent = Ghent University [Belgium] (UGENT), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Universiteit Gent = Ghent University (UGENT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE15-0015,StroMAC,Cross-talk des macrophages et du stroma au sein du ganglion lymphatique(2017) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell Survival medicine.medical_treatment [SDV]Life Sciences [q-bio] Immunology Niche Biology 03 medical and health sciences 0302 clinical medicine Immune system medicine Immunology and Allergy Macrophage Animals Homeostasis Humans Tissue homeostasis ComputingMilieux_MISCELLANEOUS Ecological niche Growth factor Interleukins Macrophage Colony-Stimulating Factor Macrophages Granulocyte-Macrophage Colony-Stimulating Factor Colony-stimulating factor Cell biology 030104 developmental biology Infectious Diseases Cellular Microenvironment Organ Specificity 030220 oncology & carcinogenesis Function (biology) |
| Zdroj: | Immunity Immunity, Elsevier, 2020, 52 (3), pp.434-451. ⟨10.1016/j.immuni.2020.02.015⟩ Immunity, 2020, 52 (3), pp.434-451. ⟨10.1016/j.immuni.2020.02.015⟩ |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2020.02.015⟩ |
| Popis: | Summary Self-maintaining resident macrophages populate all mammalian organs. In addition to their role as immune sentinels, macrophages perform day-to-day functions essential to tissue homeostasis. The homeostatic functions of macrophages are regulated by so-called tissular “niches” that control the size of the macrophage population and imprint their tissue-specific identity. Here, we review the mechanisms underlying self-maintenance of distinct macrophage populations and outline the organizing principles of the macrophage niche. We examine recent studies that uncovered mutually beneficial cell-cell circuits established between macrophages and their niche and propose a modular view of tissues that integrates the resident macrophage as an essential component of each individual module. Manipulating macrophage niche cells to control the function of resident macrophages in vivo might have therapeutic value in various disease settings. |
| Databáze: | OpenAIRE |
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