Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia

Autor: Elena Crescioli, Thomas Lass Klitgaard, Lone Musaeus Poulsen, Bjørn Anders Brand, Martin Siegemund, Thorbjørn Grøfte, Frederik Keus, Ulf Gøttrup Pedersen, Minna Bäcklund, Johanna Karttunen, Matthew Morgan, Andrei Ciubotariu, Anne-Marie Gellert Bunzel, Stine Rom Vestergaard, Nicolaj Munch Jensen, Thomas Steen Jensen, Maj-Brit Nørregaard Kjær, Aksel Karl Georg Jensen, Theis Lange, Jørn Wetterslev, Anders Perner, Olav Lilleholt Schjørring, Bodil Steen Rasmussen
Přispěvatelé: Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
Rok vydání: 2022
Předmět:
Zdroj: Intensive care medicine, 48. SPRINGER
Crescioli, E, Klitgaard, T L, Poulsen, L M, Brand, B A, Siegemund, M, Grøfte, T, Keus, F, Pedersen, U G, Bäcklund, M, Karttunen, J, Morgan, M, Ciubotariu, A, Bunzel, A-M G, Vestergaard, S R, Jensen, N M, Jensen, T S, Kjær, M-B N, Jensen, A K G, Lange, T, Wetterslev, J, Perner, A, Schjørring, O L & Rasmussen, B S 2022, ' Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia ', Intensive Care Medicine, vol. 48, no. 6, pp. 714-722 . https://doi.org/10.1007/s00134-022-06695-0
ISSN: 1432-1238
0342-4642
Popis: PURPOSE: We assessed outcomes after 1 year of lower versus higher oxygenation targets in intensive care unit (ICU) patients with severe hypoxaemia.METHODS: Pre-planned analyses evaluating 1-year mortality and health-related quality-of-life (HRQoL) outcomes in the previously published Handling Oxygenation Targets in the ICU trial which randomised 2928 adults with acute hypoxaemia to targets of arterial oxygen of 8 kPa or 12 kPa throughout the ICU stay up to 90 days. One-year all-cause mortality was assessed in the intention-to-treat population. HRQoL was assessed using EuroQol 5 dimensions 5 levels (EQ-5D-5L) questionnaire and EQ visual analogue scale score (EQ-VAS), and analyses were conducted in both survivors only and the intention-to-treat population with assignment of the worst scores to deceased patients.RESULTS: We obtained 1-year vital status for 2887/2928 (98.6%), and HRQoL for 2600/2928 (88.8%) of the trial population. One year after randomisation, 707/1442 patients (49%) in the lower oxygenation group vs. 704/1445 (48.7%) in the higher oxygenation group had died (adjusted risk ratio 1.00; 95% confidence interval 0.93-1.08, p = 0.92). In total, 1189/1476 (80.4%) 1-year survivors participated in HRQoL interviews: median EQ-VAS scores were 65 (interquartile range 50-80) in the lower oxygenation group versus 67 (50-80) in the higher oxygenation group (p = 0.98). None of the five EQ-5D-5L dimensions differed between groups.CONCLUSION: Among adult ICU patients with severe hypoxaemia, a lower oxygenation target (8 kPa) did not improve survival or HRQoL at 1 year as compared to a higher oxygenation target (12 kPa).
Databáze: OpenAIRE
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